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- Title
Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients.
- Authors
Guoyu Tong; Xiaomin Hua; Yingjie Zhong; Kui Zhang; Guangyu Gu; Wenhuan Feng; Hong Huang; Weimin Wang; Lirong Li; Yanjun Sun; Tianyan Zhang; Yun Hu
- Abstract
Objective: Many studies have shown that low sex hormone-binding globulin (SHBG) is associated with insulin resistance, but only few studies have examined how serum SHBG is regulated by insulin in humans. This interventional study aimed to investigate the effect of insulin therapy (IT) on serum SHBG levels in newly diagnosed type 2 diabetic patients. Methods: A total of 80 newly diagnosed type 2 diabetic subjects were enrolled and randomly grouped into a 2-week intensive IT with/without metformin. Serum SHBG, total testosterone, glucose, liver enzymes, lipids, insulin, and C-peptide levels were measured before and after IT. Results: Before IT, serum SHBG levels were negatively correlated with BMI, waist circumference (WC), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (?-GT), triglyceride (TG), fasting insulin, and C-peptide, and homeostatic model assessment of insulin resistance (HOMA-IR), and positively with HDL-C (all P for trend <0.05), after adjustment for age and sex. IT increased serum SHBG levels from 26.5±14.5 to 33.2±15.0?nmol/l (P<0.001), increased by 25.2% (95% CI, 20.3 to 30.9%, P<0.001). In a multiple linear regression model adjusting for age, sex, BMI, and WC, the decreases in ?ALT (standardized regression coefficient ß=-0.374, P=0.012) and ?TG (ß=-0.380, P=0.020) were independent contributors to the increase in ?SHBG. Conclusions: IT increases serum SHBG likely through improving insulin resistance and liver function.
- Subjects
INSULIN therapy; PHYSIOLOGICAL effects of sex hormones; TYPE 2 diabetes diagnosis; GLOBULINS; METFORMIN; TESTOSTERONE regulation
- Publication
European Journal of Endocrinology, 2014, Vol 170, Issue 2, p237
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-13-0557