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- Title
SIRT6 Inhibits Anoikis of Colorectal Cancer Cells by Down-Regulating NDRG1.
- Authors
Li, Fengying; Yu, Wentao; Zhou, Xiaoling; Hou, Jingyu; Gao, Yunyi; Zhang, Jun; Gao, Xiangwei
- Abstract
Anoikis, a form of apoptosis resulting from the loss of cell–extracellular matrix interaction, is a significant barrier to cancer cell metastasis. However, the epigenetic regulation of this process remains to be explored. Here, we demonstrate that the histone deacetylase sirtuin 6 (SIRT6) plays a pivotal role in conferring anoikis resistance to colorectal cancer (CRC) cells. The protein level of SIRT6 is negatively correlated with anoikis in CRC cells. The overexpression of SIRT6 decreases while the knockdown of SIRT6 increases detachment-induced anoikis. Mechanistically, SIRT6 inhibits the transcription of N-myc downstream-regulated gene 1 (NDRG1), a negative regulator of the AKT signaling pathway. We observed the up-regulation of SIRT6 in advanced-stage CRC samples. Together, our findings unveil a novel epigenetic program regulating the anoikis of CRC cells.
- Subjects
ANOIKIS; CANCER cells; COLORECTAL cancer; HISTONE deacetylase; GENETIC transcription
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 11, p5585
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25115585