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- Title
Produção e caracterização de anticorpos monoclonais contra toxina épsilon Clostridium perfringens Tipo D.
- Authors
Freitas, Theonys Diógenes; Heneine, Luis Guilherme Dias; Salvarani, Felipe Masiero; Silva, Rodrigo Otávio Silveira; Lima, Catarina Guimarães Rocha Dourado; Pires, Prhiscylla Sadanã; de Assis, Ronnie Antunes; Lobato, Francisco Carlos Faria
- Abstract
Clostridium perfringens type D is the aetiological agent of enterotoxemia in ruminants. The disease is caused by epsilon toxin characterized by cardiac, pulmonary, kidney and brain edema. Monoclonal antibodies were produced by using myeloma cell line P3-X63-Ag8 653 fused with spleen cells from Balb/c mice, immunized with epsilon toxoid of C. perfringens type D. Six hybrids were established secreting monoclonal antibodies of the IgM class and IgG3 subclass.
- Subjects
CLOSTRIDIUM; CLOSTRIDIAL enteritis; TYPE D enterotoxemia of sheep; CEREBRAL edema; TOXINS; IMMUNOGLOBULINS; MYOSIN antibodies
- Publication
Ciência Rural, 2009, Vol 39, Issue 1, p269
- ISSN
0103-8478
- Publication type
Article