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- Title
Cellular crosstalk during liver regeneration: unity in diversity.
- Authors
Shu, Wenzhi; Yang, Mengfan; Yang, Jiayin; Lin, Shengda; Wei, Xuyong; Xu, Xiao
- Abstract
The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal cells, including biliary epithelial cells, liver sinusoidal endothelial cells, hepatic stellate cells and kupffer cells. Interactions among various hepatocyte and nonparenchymal cells populations constitute a sophisticated regulatory network that restores liver mass and function. In addition, there are two different ways of liver regeneration, self-replication of liver epithelial cells and transdifferentiation between liver epithelial cells. The interactions among cell populations and regenerative microenvironment in the two modes are distinct. Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, which is also crucial for liver regeneration. 2NENg9NGXJ9EkSo_ijHnuU Video abstract
- Subjects
LIVER cells; KUPFFER cells; CELL populations; EPITHELIAL cells; ENDOTHELIAL cells; LIVER regeneration
- Publication
Cell Communication & Signaling, 2022, Vol 20, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-022-00918-z