We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The association between carotid intima-media thickness and new-onset hypertension in a Chinese community-based population.
- Authors
Zhang, Long; Fan, Fangfang; Qi, Litong; Jia, Jia; Yang, Ying; Li, Jianping; Zhang, Yan
- Abstract
<bold>Background: </bold>Hypertension and arterial vasculopathy may be mutual causes and effects. It is unknown whether carotid intima-media thickness (cIMT) is reliably predictive of the presence of newly developed hypertension in the Chinese population. This study evaluated the impacts of cIMT on new-onset hypertension in a community-based population without hypertension at baseline in China.<bold>Methods: </bold>A total of 672 Chinese subjects who had complete data for demographics, baseline and follow-up blood pressure measurements, and cIMT measurements at baseline were included in our study. Baseline cIMT was obtained under standardized procedures using the GE Vivid 7 ultrasound system equipped with an 8-MHz linear array vascular probe (GE Medical Systems, Milwaukee, Wl, USA). The outcome was the incidence of hypertension at follow-up. Multivariate regression models were used to access the association between baseline cIMT and the risk of new-onset hypertension.<bold>Results: </bold>Subjects were 51.5 ± 4.7 years old, and 32.0% were male. The mean baseline systolic blood pressure (SBP) was 122.5 ± 10.0 mmHg. The mean baseline diastolic blood pressure (DBP) was 72.4 ± 7.5 mmHg. The number of subjects with thickened cIMT (maximum ≥0.9 mm) at baseline was 198 (29.5%). After 2.3 years of follow-up, the rate of new-onset hypertension was 12.6%. The incidence rates of hypertension in the groups with thickened cIMT and normal cIMT were 19.2 and 9.9%, respectively. In the multivariable logistic regression analyses, both the average (OR = 1.69, 95% CI: 1.30-2.19, P = 0.0001) and maximum (OR = 1.55, 95% CI: 1.23-1.95, P = 0.0002) cIMT were significantly associated with new-onset hypertension after adjustment for various confounders. The group with thickened cIMT showed a higher risk for the incidence of hypertension, with an OR of 1.82 (95% CI: 1.07-3.10, P = 0.0270), compared to the normal group.<bold>Conclusion: </bold>Thickened cIMT has a strong association with incident hypertension risk in a community-based population without hypertension at baseline in China.
- Subjects
CHINA; MILWAUKEE (Wis.); CAROTID intima-media thickness; GE Healthcare Inc.; SYSTOLIC blood pressure; HYPERTENSION; BLOOD pressure; LOGISTIC regression analysis
- Publication
BMC Cardiovascular Disorders, 2019, Vol 19, Issue 1, p1
- ISSN
1471-2261
- Publication type
journal article
- DOI
10.1186/s12872-019-1266-1