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- Title
Src and Epidermal Growth Factor Receptor: Novel Partners in Mediating Chronic Hypoxia--induced Pulmonary Artery Hypertension.
- Authors
Yuansheng Gao; Raj, J. Usha
- Abstract
The editor discusses a study exploring how enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase. It further elaborates how increased activity of the RhoA/Rho kinase (RhoA/ROCK) signaling pathway is a key feature in the development of pulmonary arterial hypertension (PAH) and the associated pulmonary vascular remodeling under various pathophysiological conditions, including chronic hypoxia.
- Subjects
VASOCONSTRICTION; NAD(P)H dehydrogenases; PULMONARY artery abnormalities; HYPOXEMIA; VASCULAR remodeling
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2020, Vol 62, Issue 1, p5
- ISSN
1044-1549
- Publication type
Editorial
- DOI
10.1165/rcmb.2019-0230ED