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- Title
Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.
- Authors
Wichmann, Ole; Muehlen, Marion; Gruss, Holger; Mockenhaupt, Frank P.; Suttorp, Norbert; Jelinek, Tomas
- Abstract
Malarone® (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's cytochrome b gene. We report the first case of Malarone® treatment failure from Central Africa. Drug concentration was well within curative range. Pre- and post-treatment Plasmodium falciparum isolates revealed codon 268 wild-type alleles, and no other mutations of the putative atovaquonebinding domain. These findings illustrate the spread of atovaquone-proguanil-resistance in Africa and question the usefulness of codon 268 as the only target for the surveillance of its emergence.
- Subjects
AFRICA; MALARIA; CYTOCHROME b; GENES; GENETIC mutation
- Publication
Malaria Journal, 2004, Vol 3, p14
- ISSN
1475-2875
- Publication type
Article
- DOI
10.1186/1475-2875-3-14