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- Title
Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities.
- Authors
Trindade-Suedam, Ivy Kiemle; von Kostrisch, Lília Maria; Freire Pimenta, Luiz André; Negrato, Carlos Antônio; Braga Franzolin, Solange; Trindade Junior, Alceu Sergio
- Abstract
Objective: to assessed the prevalence of diabetes mellitus (DM) and drug abuse in mothers of children with orofacial clefts (OFC). Methods: 325 women who had children (0-3y) with clefts were interviewed. Data regarding type of diabetes, use of legal/illegal drugs during pregnancy, waist girth and fasting blood sugar at the first prenatal consult were collected. Results: twenty seven percent of the women had DM, out of these, 89% had gestational DM, 5,5% type 1 DM and 5,5% type 2 DM. The prevalence of DM in mothers of children with OFC was 27%, it is significantly higher than the average Brazilian population which is 7.6% (p<0.01) (OR=4.5, 95%CI = 3.5-5.8). Regarding drug abuse during pregnancy, 32% of the mothers used drugs and a significant positive correlation was observed between drug abuse and the occurrence of clefts and other craniofacial anomalies (p=0.028) (OR=2.87; 95%CI=1.1-7.4). Conclusions: DM and drug abuse during pregnancy increases the risk for OFC and related anomalies and early diagnosis of DM and prevention of drug abuse, especially in pregnant women, should be emphasized.
- Subjects
BRAZIL; CLEFT palate; CONFIDENCE intervals; GESTATIONAL diabetes; MOTHERS; SUBSTANCE abuse in pregnancy; CROSS-sectional method; ODDS ratio; DISEASE risk factors
- Publication
Revista Latino-Americana de Enfermagem (RLAE), 2016, Vol 24, p1
- ISSN
1518-8345
- Publication type
Article
- DOI
10.1590/1518-8345.0815.2701