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- Title
MTHFR C677T polymorphism associates with unexplained infertile male factors.
- Authors
Jung Hoon Park; Lee, Han Chul; Yu-Mi Jeong; Tae-Gyu Chung; Hyun-Joo Kim; Nam Keun Kim; Sook-Hwan Lee; Suman Lee
- Abstract
Purpose: To determine whether 5,10-methylenetetrahydrofolate reductase (M'THFR C677') and A1298C) genotype is associated with male infertility. Methods: Analysis of cytogenetic, Y chromosomal microdeletion assay (Yq), and the C677'T' and A1298C polymorphisms of the MTHFR gene by pyrosequencing and PCR-Restriction Fragment Length Polymorphism (RFLP) method. SAS 8.1 assessed the statistical risk of MTHFR genotype. Results:The homozygous (T/T) C677'T' polymorphism of the MTHFR gene was present at a statistically high significance in unexplained infertile men with normal karyotype, instead at no significance in explained infertile men with chromosomal abnormality or Y chromosome deletion. There was no statistically significance of A1298C variation in infertile males. Conclusions: The Mi'! IFR 677'IT genotype may he a genetic risk factor for male infertility. especially with severe OA'I' and non-obstructive azoospermia in unexplained infertile males.
- Subjects
GENETIC polymorphisms; INFERTILITY; GENES; CHROMOSOME abnormalities; HUMAN fertility; GENITAL diseases
- Publication
Journal of Assisted Reproduction & Genetics, 2005, Vol 22, Issue 9/10, p361
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-005-6795-0