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- Title
Suppression of AGE Precursor Formation Following Unilateral Ureteral Obstruction in Mouse Kidneys by Transgenic Expression of α-Dicarbonyl/L-Xylulose Reductase.
- Authors
Asami, Jun; Odani, Fliroko; Ishii, Aiko; Oide, Kayoko; Sudo, Takako; Nakamura, Atsushi; Miyata, Noriyuki; Otsuka, Noboru; Maeda, Kenji; Nakagawa, Junichi
- Abstract
The article presents a study on the relevance of DCXR in the clearance of oxidative stress and subsequent fibrosis by using unilateral ureteral obstruction (UUO). The content of methyl glyoxal, glyoxal, and 3-deoxyglucosone in mouse extracts can be measured by electrospray ionization, liquid chromatography, and mass spectrometry following UUO. On the other hand, the content of collagen III in kidneys showed no difference as monitored by in situ hybridization.
- Subjects
MEDICAL research; URINARY organs; NUCLEIC acid hybridization; KIDNEYS; TRANSGENIC mice
- Publication
Bioscience, Biotechnology & Biochemistry, 2006, Vol 70, Issue 12, p2899
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.60311