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- Title
Cover Feature: Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the trans‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates (Chem. Eur. J. 40/2021).
- Authors
Matinkhoo, Kaveh; Wong, Antonio A. W. L.; Hambira, Chido M.; Kato, Brandon; Wei, Charlie; Müller, Christoph; Hechler, Torsten; Braun, Alexandra; Gallo, Francesca; Pahl, Andreas; Perrin, David M.
- Abstract
Cover Feature: Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates (Chem. Eur. J. 40/2021) Keywords: Amanitin; amatoxin; antibody-drug conjugates; hydroxyproline; peptides EN Amanitin amatoxin antibody-drug conjugates hydroxyproline peptides 10212 10212 1 07/19/21 20210716 NES 210716 B Probing the hydroxyproline residue b (Hyp) of alpha-amanitin, this structural activity relationship study investigates the conformation and H-bonding network of the first Hyp-analogs of the extremely toxic, RNA polymerase II inhibiting, fungal octapeptide for its potential as a warhead in antibody-drug conjugates. Amanitin, amatoxin, antibody-drug conjugates, hydroxyproline, peptides.
- Subjects
ANTIBODY-drug conjugates; RNA polymerase II
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 40, p10212
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202102062