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Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening.
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- Pharmaceutics, 2021, v. 13, n. 10, p. 1598, doi. 10.3390/pharmaceutics13101598
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- Article
Site-Selective Labeling of a Lysine Residue in Human Serum Albumin.
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- Angewandte Chemie International Edition, 2014, v. 53, n. 44, p. 11783, doi. 10.1002/anie.201405924
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- Article
Rapid, Stable, Chemoselective Labeling of Thiols with Julia-Kocieński-like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation.
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- Angewandte Chemie International Edition, 2013, v. 52, n. 48, p. 12592, doi. 10.1002/anie.201306241
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- Article
Core-Structure-Motivated Design of Iminium-Enolate Organocascade Reactions: Enantioselective Syntheses of 5,6-Dihydroindolizines.
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- Angewandte Chemie International Edition, 2013, v. 52, n. 35, p. 9261, doi. 10.1002/anie.201303300
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- Article
Vessel maneuvers: Zinc fingers promote angiogenesis.
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- Nature Medicine, 2002, v. 8, n. 12, p. 1353, doi. 10.1038/nm1202-1353
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Molecular Cloning of Aldolases for Synthetic Applications<sup>a</sup>.
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- Annals of the New York Academy of Sciences, 1990, v. 613, n. 1, p. 771, doi. 10.1111/j.1749-6632.1990.tb18262.x
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Controlling gene expression in plants using synthetic zinc finger transcription factors.
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- Plant Journal, 2002, v. 32, n. 6, p. 1077, doi. 10.1046/j.1365-313X.2002.01492.x
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Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants.
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- Nucleic Acids Research, 2014, v. 42, n. 7, p. 4755, doi. 10.1093/nar/gkt1389
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- Article
Directed evolution of the TALE N-terminal domain for recognition of all 5′ bases.
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- Nucleic Acids Research, 2013, v. 41, n. 21, p. 9779, doi. 10.1093/nar/gkt754
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- Article
A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells.
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- Nucleic Acids Research, 2013, v. 41, n. 6, p. 3937, doi. 10.1093/nar/gkt071
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- Article
Chimeric TALE recombinases with programmable DNA sequence specificity.
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- Nucleic Acids Research, 2012, v. 40, n. 21, p. 11163, doi. 10.1093/nar/gks875
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Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.
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- Nucleic Acids Research, 2011, v. 39, n. 17, p. 7868, doi. 10.1093/nar/gkr421
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- Article
Directed evolution of recombinase specificity by split gene reassembly.
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- Nucleic Acids Research, 2010, v. 38, n. 12, p. 4198, doi. 10.1093/nar/gkq125
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Willem 'Pim' Stemmer 1957-2013.
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- Nature Biotechnology, 2013, v. 31, n. 7, p. 584, doi. 10.1038/nbt.2630
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Scanning the human genome with combinatorial transcription factor libraries.
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- Nature Biotechnology, 2003, v. 21, n. 3, p. 269, doi. 10.1038/nbt794
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Engineering polydactyl zinc-finger transcription factors.
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- Nature Biotechnology, 2002, v. 20, n. 2, p. 135, doi. 10.1038/nbt0202-135
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Targeted gene knockout by direct delivery of zinc-finger nuclease proteins.
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- Nature Methods, 2012, v. 9, n. 8, p. 805, doi. 10.1038/nmeth.2030
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Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production.
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- Nature Structural & Molecular Biology, 2009, v. 16, n. 11, p. 1195, doi. 10.1038/nsmb.1677
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- Article
Site-Selective Labeling of a Lysine Residue in Human Serum Albumin.
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- Angewandte Chemie, 2014, v. 126, n. 44, p. 11977, doi. 10.1002/ange.201405924
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- Publication type:
- Article
Rapid, Stable, Chemoselective Labeling of Thiols with Julia-Kocieński-like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation.
- Published in:
- Angewandte Chemie, 2013, v. 125, n. 48, p. 12824, doi. 10.1002/ange.201306241
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- Publication type:
- Article
Core-Structure-Motivated Design of Iminium-Enolate Organocascade Reactions: Enantioselective Syntheses of 5,6-Dihydroindolizines.
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- Angewandte Chemie, 2013, v. 125, n. 35, p. 9431, doi. 10.1002/ange.201303300
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- Publication type:
- Article
Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-Coupling Strategy.
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- Angewandte Chemie, 2012, v. 124, n. 50, p. 12706, doi. 10.1002/ange.201205921
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Rationally Designed Amide Donors for Organocatalytic Asymmetric Michael Reactions.
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- Angewandte Chemie, 2012, v. 124, n. 22, p. 5477, doi. 10.1002/ange.201200996
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Expanding the Concept of Chemically Programmable Antibodies to RNA Aptamers: Chemically Programmed Biotherapeutics.
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- Angewandte Chemie, 2010, v. 122, n. 34, p. 6070, doi. 10.1002/ange.201001736
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α<sub>v</sub> Integrins mediate adhesion and migration of breast carcinoma cell lines.
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- Clinical & Experimental Metastasis, 1998, v. 16, n. 1, p. 50, doi. 10.1023/A:1006512018609
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- Article
Intrabody-based Mapping of Latency-associated Nuclear Antigen from Kaposi's Sarcoma-associated Herpesvirus Show Conserved Epitopes for Viral Latency Inhibition.
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- Virology: Research & Treatment, 2010, v. 2, p. 1, doi. 10.4137/VRT.S975
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Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering.
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- PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085755
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Expanding the scope of site-specific recombinases for genetic and metabolic engineering.
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- Biotechnology & Bioengineering, 2014, v. 111, n. 1, p. 1, doi. 10.1002/bit.25096
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Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor.
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- Oncogene, 2003, v. 22, n. 10, p. 1557, doi. 10.1038/sj.onc.1206299
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Expanding the Potential of DNA for Binding and Catalysis: Highly Functionalized dUTP Derivatives That Are Substrates for Thermostable DNA Polymerases.
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- Angewandte Chemie International Edition, 1998, v. 37, n. 20, p. 2872, doi. 10.1002/(SICI)1521-3773(19981102)37:20<2872::AID-ANIE2872>3.0.CO;2-5
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Catalytic Enantioselective Retro-Aldol Reactions: Kinetic Resolution of β-Hydroxyketones with Aldolase Antibodies.
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- Angewandte Chemie International Edition, 1998, v. 37, n. 18, p. 2481, doi. 10.1002/(SICI)1521-3773(19981002)37:18<2481::AID-ANIE2481>3.0.CO;2-T
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Negative regulation of the RTBV promoter by designed zinc finger proteins.
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- Plant Molecular Biology, 2010, v. 72, n. 6, p. 621, doi. 10.1007/s11103-010-9600-0
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- Article
A Chemically Programmed Antibody Is a Long-Lasting and Potent Inhibitor of Influenza Neuraminidase.
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- ChemBioChem, 2012, v. 13, n. 15, p. 2191, doi. 10.1002/cbic.201200439
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Potent Inhibition of HIV-1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis.
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- ChemBioChem, 2010, v. 11, n. 15, p. 2113, doi. 10.1002/cbic.201000432
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Translating the Genomics Revolution: The Need for an International Gene Therapy Consortium for Monogenic Diseases.
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- Molecular Therapy, 2013, v. 21, n. 2, p. 266, doi. 10.1038/mt.2013.4
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Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells.
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- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-56056-z
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Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases.
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- Nucleic Acids Research, 2006, v. 34, n. 11, p. w516, doi. 10.1093/nar/gkl209
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- Article
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector.
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- International Journal of Cancer, 2006, v. 119, n. 5, p. 1194, doi. 10.1002/ijc.21924
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- Article
Maspin alters the carcinoma proteome.
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- FASEB Journal, 2005, v. 19, n. 9, p. 1123, doi. 10.1096/fj.04-2970fje
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Integrin α<sub>IIb</sub>β<sub>3</sub>-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation.
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- FASEB Journal, 2004, v. 18, n. 2, p. 361, doi. 10.1096/fj.03-0586fje
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Integrin αvβ3‐targeted therapy for Kaposi's sarcoma with an in vitro‐evolved antibody.
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- FASEB Journal, 2002, v. 16, n. 14, p. 2000, doi. 10.1096/fj.02-0281fje
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- Article
Aldolase Antibody Activation of Prodrugs of Potent Aldehyde-Containing Cytotoxics for Selective Chemotherapy.
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- Chemistry - A European Journal, 2004, v. 10, n. 21, p. 5467, doi. 10.1002/chem.200400419
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Towards Organo-Click Chemistry: Development of Organocatalytic Multicomponent Reactions Through Combinations of Aldol, Wittig, Knoevenagel, Michael, DielsAlder and Huisgen Cycloaddition Reactions.
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- Chemistry - A European Journal, 2004, v. 10, n. 21, p. 5323
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Cover Picture: Towards Organo-Click Chemistry: Development of Organocatalytic Multicomponent Reactions Through Combinations of Aldol, Wittig, Knoevenagel, Michael, DielsAlder and Huisgen Cycloaddition Reactions (Chem. Eur. J. 21/2004).
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- Chemistry - A European Journal, 2004, v. 10, n. 21, p. 5255
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Prodrug Activation Gated by a Molecular “OR” Logic TriggerR.J.A. and M.P. contributed equally to this work. D.S. thanks the Israel Science Foundation for financial support.
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- Angewandte Chemie, 2005, v. 117, n. 28, p. 4452, doi. 10.1002/ange.200500842
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Direct Asymmetric α-Fluorination of AldehydesThis study was supported by the NIH (CA27489).
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- Angewandte Chemie, 2005, v. 117, n. 24, p. 3772, doi. 10.1002/ange.200500571
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Single-Triggered Trimeric ProdrugsD.S. thanks the Israel Science Foundation for financial support. We thank Dr. Michael Meijler for his helpful comments. K.H. and M.P. contributed equally to this work.
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- Angewandte Chemie, 2005, v. 117, n. 5, p. 726, doi. 10.1002/ange.200461657
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Synthesis of β-Hydroxyaldehydes with Stereogenic Quaternary Carbon Centers by Direct Organocatalytic Asymmetric Aldol Reactions ( This study was supported in part by the NIH (CA27489) and by The Skaggs Institute for Chemical Biology. ).
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- Angewandte Chemie, 2004, v. 116, n. 18, p. 2474, doi. 10.1002/ange.200353546
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Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane-1,5,9-trionesThis study was supported in part by the National Institutes of Health (CA27489) and the Skaggs Institute for Chemical Biology. We thank Dr. Raj K. Chadha for X-ray structural analysis.
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- Angewandte Chemie, 2003, v. 115, n. 35, p. 4365, doi. 10.1002/ange.200351916
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An Efficient Benchtop System for Multigram-Scale Kinetic Resolutions Using Aldolase Antibodies.
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- Chemistry - A European Journal, 2000, v. 6, n. 15, p. 2772, doi. 10.1002/1521-3765(20000804)6:15<2772::AID-CHEM2772>3.0.CO;2-J
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