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- Title
Facile design of biomaterials by 'click' chemistry.
- Authors
Hvilsted, Søren
- Abstract
The advent of the so-called 'click chemistry' a decade ago has significantly improved the chemical toolbox for producing novel biomaterials. This review focuses primarily on the application of Cu(I)-catalysed azide-alkyne 1,3-cycloadditon in the preparation of numerous, diverse biomaterials and biomedical materials and concepts. In addition, the thiol-ene 'click' reaction is addressed in the same manner, and the possibility of using both click reactions orthogonally is highlighted. A strategy for the preparation of novel intriguing poly(ε-caprolactone)-based nanobiomaterials by orthogonal click chemistry is elaborated. The present state of creating functional and biologically active surfaces by click chemistry is presented. Finally, conducting surfaces based on an azide-functionalized polymer with prospective biological sensor potential are introduced. Copyright © 2012 Society of Chemical Industry
- Subjects
AZIDES; NITROGEN compounds; CLICK chemistry; CHEMISTRY; CAPROLACTONES
- Publication
Polymer International, 2012, Vol 61, Issue 4, p485
- ISSN
0959-8103
- Publication type
Article
- DOI
10.1002/pi.4135