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- Title
Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma.
- Authors
Zaki, Mona; Wada, Naoki; Ikeda, Junichiro; Shibayama, Hirohiko; Hashimoto, Koji; Yamagami, Tamotsu; Tatsumi, Yoichi; Tsukaguchi, Machiko; Take, Hironori; Tsudo, Mitsuru; Morii, Eiichi; Aozasa, Katsuyuki; Zaki, Mona A A
- Abstract
To evaluate roles of tumor-associated macrophages (TAMs) for prognosis of classical Hodgkin lymphoma (CHL). Expression of markers for TAMs, CD68, HLA-DR, CD163, HLA-DR/CD68 (M1), and CD163/CD68 (M2) was immunohistochemically examined in 82 cases with CHL. Positively stained cells were counted and correlation of number of TAMs and patients' survival time was analyzed. Number of CD163+ cells and M2 cells was significantly correlated with shorter overall survival (P < 0.05), while it was marginally significant for CD68+ cells (P = 0.0827). HLA-DR + cells and M1 cells showed no significant correlation with overall survival. When confined to mixed cellularity subtype, number of M1 cells was correlated with favorable prognosis (P < 0.05), while M2 did not (P = 0.7). Older age and male sex were unfavorable factors for prognosis. At multivariate analysis, number of CD163+ cells, M2+ cells, and age were independent factors for poor overall survival (P = 0.03, 0.02, and 0.01, respectively). CD163+ cells and M2 cells might work to be tumor promotive in CHL. M1 cells might be tumor suppressive in mixed cellularity type.
- Subjects
MACROPHAGES; HODGKIN'S disease; GENE expression; CANCER cells; TUMORS
- Publication
Virchows Archiv: European Journal of Pathology, 2011, Vol 459, Issue 4, p361
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-011-1140-8