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- Title
Total Synthesis of Incarnatapeptins A and B.
- Authors
Han, Feipeng; Li, Jie; Li, Shupeng; Wang, Zhuo; Guo, Yian; Ye, Tao
- Abstract
The first total synthesis of incarnatapeptins A and B, two novel marine natural products, was accomplished from readily available (S)‐1‐benzyloxycarbonylhexahydropyridazine‐3‐carboxylic acid. This route, whose longest linear sequence was 12 steps, provided the incarnatapeptins A and B in yields of 26.5 % and 19.7 %, respectively, and enabled the structure and stereochemistry of both natural products to be unambiguously confirmed. Highlights of our synthesis include the photoredox‐mediated decarboxylative 1,4‐addition reaction and a novel and practical N‐acylation paradigm promoted by silver carbonate. The unusual facile atropisomerism of some linear peptidic intermediates was also observed by TLC analysis in the course of this work.
- Subjects
MARINE natural products; NATURAL products; STEREOCHEMISTRY; ACYLATION
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 9, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202317636