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- Title
Vitamin A: Is It a Risk Factor for Osteoporosis and Bone Fracture?
- Authors
Ribaya-Mercado, Judy D.; Blumberg, Jeffrey B.
- Abstract
Results from observational studies of the association between vitamin A intake or serum concentration and bone mineral density or fracture are mixed. The inconsistencies may be due, in part, to difficulties in obtaining an accurate assessment of vitamin A intake or status. Serum retinol is a poor measure of vitamin A status because it is subject to homeostatic control. Stable-isotope-dilution methodology gives a validated assessment of the total-body and liver vitamin A stores and is recommended in future studies on vitamin A status and osteoporosis. The potential for exacerbating an already serious public health problem with intakes of vitamin A currently considered safe indicates further research into this matter is warranted.
- Subjects
VITAMIN A; RETINOIDS; VITAMIN A deficiency; VITAMIN A in human nutrition; OSTEOPOROSIS; BONE diseases; HOMEOSTASIS
- Publication
Nutrition Reviews, 2007, Vol 65, Issue 10, p425
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1301/nr.2007.oct.425438