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- Title
Circulating Matrix Metalloproteinase-9 is Transiently Elevated in Response to Surgical Stress.
- Authors
de Hingh, I. H. J. T.; Waas, E. T.; Lomme, R. M. L. M.; Wobbes, T.; Hendriks, T.
- Abstract
This article focuses on a study which shows that circulating matrix metalloproteinase-9 is transiently elevated in response to surgical stress. Matrix Metalloproteinases are enzymes capable of degrading and remodeling essentially all components of the extracellular matrix and these enzymes are thought to be crucial for typical malignant properties such as infiltrative growth and outgrowth of metastases. The present data show that proMMP-9 activity in plasma is temporarily increased in response to surgical stress while activity of proMMP-2 is not affected. This finding may have important consequences for the possible use of circulating MMPs as markers for the progression of various malignancies.
- Subjects
METALLOPROTEINASES; METALLOENZYMES; EXTRACELLULAR space; PROTEINASES; ENZYMOLOGY; PATHOLOGY
- Publication
European Surgical Research, 2004, Vol 36, p76
- ISSN
0014-312X
- Publication type
Article