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- Title
Relationship between Neutrophil-to-Lymphocyte Ratio and Left Ventricular Free Wall Rupture in Acute Myocardial Infarction.
- Authors
Ipek, Gokturk; Onuk, Tolga; Karatas, Mehmet Baran; Güngör, Barış; atasoy, Isıl; Murat, ahmet; aldag, Mustafa; Yelgec, Nizamettin Selcuk; Dayi, Sennur Unal; Bolca, Osman
- Abstract
Objectives: This study aimed to evaluate the relationship between the neutrophil-to-lymphocyte (N/L) ratio and left ventricular free wall rupture (LVFWR) in patients with ST elevation myocardial infarction (STEMI). Previous studies showed a correlation between increased levels of inflammatory markers and adverse cardiovascular events. The role of inflammation markers, particularly the N/L ratio, in mechanical complications after myocardial infarction has not been studied. Methods: Retrospectively, we compared the N/L ratio values of 23 patients with STEMI complicated by LVFWR with 214 STEMI patients without this complication. The diagnosis of rupture was confirmed by echocardiography in each case. Results: Neutrophil counts [median 8.5 × 103/µl, interquartile range (IQR) 6.4, vs. 7.8 × 103/µl, IQR 4.7, p = 0.02] and the N/L ratio (5.66, IQR 4.17, vs. 4.1, IQR 3.93, p = 0.01) were significantly higher in the LVFWR group. In receiver operating characteristic analysis, an N/L ratio above 3.7 predicted LVFWR with a sensitivity of 82.6% and a specificity of 46.9% (area under the curve = 0.654, p = 0.016). In multivariate regression analysis, age, hypertension, increased creatinine levels and increased N/L ratio (odds ratio = 1.61, 95% confidence interval = 1.15-2.23, p = 0.01) were found to be independent predictors of LVFWR. Conclusions: In our study, the N/L ratio was found to be independently correlated with the risk of LVFWR. © 2015 S. Karger AG, Basel
- Subjects
NEUTROPHILS; LYMPHOCYTES; LEFT heart ventricle; HEART rupture; MYOCARDIAL infarction; ECHOCARDIOGRAPHY; PATIENTS
- Publication
Cardiology, 2015, Vol 132, Issue 2, p105
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000431354