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The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity.
Published in:
Advanced Science, 2024, v. 11, n. 36, p. 1, doi. 10.1002/advs.202401085
By:
- Chen, Jianan;
- Yang, Junhua;
- Chu, Jiachen;
- Chen, Kevin Hong;
- Alt, Jesse;
- Rais, Rana;
- Qiu, Zhaozhu
Publication type:
Article
Regional brain distribution of translocator protein using [C]DPA-713 PET in individuals infected with HIV.
Published in:
Journal of NeuroVirology, 2014, v. 20, n. 3, p. 219, doi. 10.1007/s13365-014-0239-5
By:
- Coughlin, Jennifer;
- Wang, Yuchuan;
- Ma, Shuangchao;
- Yue, Chen;
- Kim, Pearl;
- Adams, Ashley;
- Roosa, Heidi;
- Gage, Kenneth;
- Stathis, Marigo;
- Rais, Rana;
- Rojas, Camilo;
- McGlothan, Jennifer;
- Watkins, Crystal;
- Sacktor, Ned;
- Guilarte, Tomas;
- Zhou, Yun;
- Sawa, Akira;
- Slusher, Barbara;
- Caffo, Brian;
- Kassiou, Michael
Publication type:
Article
Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways.
Published in:
Cancers, 2022, v. 14, n. 5, p. 1311, doi. 10.3390/cancers14051311
By:
- Pham, Khoa;
- Hanaford, Allison R.;
- Poore, Brad A.;
- Maxwell, Micah J.;
- Sweeney, Heather;
- Parthasarathy, Akhila;
- Alt, Jesse;
- Rais, Rana;
- Slusher, Barbara S.;
- Eberhart, Charles G.;
- Raabe, Eric H.
Publication type:
Article
Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis.
Published in:
Nanotheranostics, 2022, v. 6, n. 2, p. 126, doi. 10.7150/ntno.63158
By:
- Hollinger, Kristen R.;
- Sharma, Anjali;
- Tallon, Carolyn;
- Lovell, Lyndah;
- Thomas, Ajit G.;
- Xiaolei Zhu;
- Wiseman, Robyn;
- Ying Wu;
- Kambhampati, Siva P.;
- Liaw, Kevin;
- Sharma, Rishi;
- Rojas, Camilo;
- Rais, Rana;
- Kannan, Sujatha;
- Kannan, Rangaramanujam M.;
- Slusher, Barbara S.
Publication type:
Article
Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity.
Published in:
Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01547-9
By:
- Fu, Xiuping;
- Shah, Aparna P.;
- Keighron, Jacqueline;
- Mou, Ta-Chung M.;
- Ladenheim, Bruce;
- Alt, Jesse;
- Fukudome, Daisuke;
- Niwa, Minae;
- Tamashiro, Kellie L.;
- Tanda, Gianluigi;
- Sawa, Akira;
- Cadet, Jean-Lud;
- Rais, Rana;
- Baraban, Jay M.
Publication type:
Article
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Published in:
Science Translational Medicine, 2023, v. 15, n. 708, p. 1, doi. 10.1126/scitranslmed.abn7491
By:
- Peters, Diane E.;
- Norris, Lauren D.;
- Tenora, Lukáš;
- Šnajdr, Ivan;
- Ponti, András K.;
- Zhu, Xiaolei;
- Sakamoto, Shinji;
- Veeravalli, Vijayabhaskar;
- Pradhan, Manisha;
- Alt, Jesse;
- Thomas, Ajit G.;
- Majer, Pavel;
- Rais, Rana;
- McDonald, Christine;
- Slusher, Barbara S.
Publication type:
Article
Method to Screen Substrates of Apical Sodium-Dependent Bile Acid Transporter.
Published in:
AAPS Journal, 2008, v. 10, n. 4, p. 596, doi. 10.1208/s12248-008-9069-9
By:
- Rais, Rana;
- Gonzalez, Pablo;
- Zheng, Xiaowan;
- Wring, Stephen;
- Polli, James
Publication type:
Article
Inhibition of EV biogenesis reduces tau propagation in Alzheimer's Disease mouse models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.078341
By:
- Huang, Meixiang;
- Tallon, Carolyn;
- Bell, Benjamin J;
- Kapogiannis, Dimitrios;
- Haughey, Norman J;
- Rais, Rana;
- Slusher, Barbara S
Publication type:
Article
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-36144-2
By:
- Rojas, Camilo;
- Barnaeva, Elena;
- Thomas, Ajit G.;
- Hu, Xin;
- Southall, Noel;
- Marugan, Juan;
- Chaudhuri, Amrita Datta;
- Yoo, Seung-Wan;
- Hin, Niyada;
- Stepanek, Ondrej;
- Wu, Ying;
- Zimmermann, Sarah C.;
- Gadiano, Alexandra G.;
- Tsukamoto, Takashi;
- Rais, Rana;
- Haughey, Norman;
- Ferrer, Marc;
- Slusher, Barbara S.
Publication type:
Article
Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Published in:
2021
By:
- Nedelcovych, Michael T.;
- Kim, Boe-Hyun;
- Zhu, Xiaolei;
- Lovell, Lyndah E.;
- Manning, Arena A.;
- Kelschenbach, Jennifer;
- Hadas, Eran;
- Chao, Wei;
- Prchalová, Eva;
- Dash, Ranjeet P.;
- Wu, Ying;
- Alt, Jesse;
- Thomas, Ajit G.;
- Rais, Rana;
- Kamiya, Atsushi;
- Volsky, David J.;
- Slusher, Barbara S.
Publication type:
Correction Notice
Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Published in:
Journal of NeuroImmune Pharmacology, 2019, v. 14, n. 3, p. 391, doi. 10.1007/s11481-019-09859-w
By:
- Nedelcovych, Michael T.;
- Kim, Boe-Hyun;
- Zhu, Xiaolei;
- Lovell, Lyndah E.;
- Manning, Arena A.;
- Kelschenbach, Jennifer;
- Hadas, Eran;
- Chao, Wei;
- Prchalová, Eva;
- Dash, Ranjeet P.;
- Wu, Ying;
- Alt, Jesse;
- Thomas, Ajit G.;
- Rais, Rana;
- Kamiya, Atsushi;
- Volsky, David J.;
- Slusher, Barbara S.
Publication type:
Article
Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis En Route.
Published in:
Advanced Synthesis & Catalysis, 2016, v. 358, n. 9, p. 1482, doi. 10.1002/adsc.201501101
By:
- Barbour, Patrick M.;
- Wang, Wei;
- Chang, Le;
- Pickard, Kasey L.;
- Rais, Rana;
- Slusher, Barbara S.;
- Wang, Xiang
Publication type:
Article
ATRT-04. UNBIASED METABOLIC PROFILING OF ATYPICAL TERATOID/RHABDOID TUMORS PREDICTS SENSITIVITY TO GLUTAMINE METABOLIC INHIBITORS.
Published in:
Neuro-Oncology, 2019, v. 21, p. ii63, doi. 10.1093/neuonc/noz036.003
By:
- Wang, Sabrina;
- Poore, Brad;
- Alt, Jesse;
- Price, Antoinette;
- Allen, Sariah;
- Orr, Brent;
- Rais, Rana;
- Slusher, Barbara;
- Eberhart, Charles;
- Raabe, Eric;
- Rubens, Jeffrey
Publication type:
Article
Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D<sub>2</sub>-Like Receptor Signaling in Dysglycemia.
Published in:
Diabetes, 2024, v. 73, n. 9, p. 1411, doi. 10.2337/db24-0175
By:
- Bonifazi, Alessandro;
- Ellenberger, Michael;
- Farino, Zachary J.;
- Aslanoglou, Despoina;
- Rais, Rana;
- Pereira, Sandra;
- Mantilla-Rivas, José O.;
- Boateng, Comfort A.;
- Eshleman, Amy J.;
- Janowsky, Aaron;
- Hahn, Margaret K.;
- Schwartz, Gary J.;
- Slusher, Barbara S.;
- Newman, Amy Hauck;
- Freyberg, Zachary
Publication type:
Article
A review of bioanalytical quantitative methods for selected sphingosine 1-phosphate receptor modulators.
Published in:
Biomedical Chromatography, 2018, v. 32, n. 1, p. n/a, doi. 10.1002/bmc.4109
By:
- Dash, Ranjeet Prasad;
- Srinivas, Nuggehally R.;
- Rais, Rana
Publication type:
Article
Quantitation of unbound sunitinib and its metabolite N-desethyl sunitinib (SU12662) in human plasma by equilibrium dialysis and liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Published in:
Biomedical Chromatography, 2012, v. 26, n. 11, p. 1315, doi. 10.1002/bmc.2697
By:
- Rais, Rana;
- Zhao, Ming;
- He, Ping;
- Xu, Linping;
- Deeken, John F.;
- Rudek, Michelle A.
Publication type:
Article
A novel and potent brain penetrant inhibitor of extracellular vesicle release.
Published in:
2019
By:
- Rojas, Camilo;
- Sala, Michal;
- Thomas, Ajit G.;
- Datta Chaudhuri, Amrita;
- Yoo, Seung‐Wan;
- Li, Zhigang;
- Dash, Ranjeet P.;
- Rais, Rana;
- Haughey, Norman J.;
- Nencka, Radim;
- Slusher, Barbara;
- Yoo, Seung-Wan
Publication type:
journal article
nSMase2 inhibition reduces tau propagation in Alzheimer's Disease mouse models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.063639
By:
- Tallon, Carolyn;
- Bell, Benjamin J;
- Malvankar, Medhinee;
- Thomas, Ajit G;
- Yoo, Seung Wan;
- Pal, Arindom;
- Wu, Ying;
- Coleman, Kaleem;
- Joe, Tawnjerae R;
- Sharma, Anjali;
- Eren, Erden;
- Zhu, Xiaolei;
- Kannan, Rangaramanujam M;
- Kapogiannis, Dimitrios;
- Haughey, Norman J;
- Rais, Rana;
- Slusher, Barbara S
Publication type:
Article
The neutral sphingomyelinase 2 inhibitor PDDC reduces tau burden in Alzheimer's disease mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.054502
By:
- Tallon, Carolyn;
- Bell, Benjamin J;
- Malvankar, Medhinee;
- Hollinger, Kristen R;
- Thomas, Ajit G;
- Yoo, Seung Wan;
- Chaudhuri, Amrita Datta;
- Wu, Ying;
- Rais, Rana;
- Haughey, Norman J;
- Slusher, Barbara S
Publication type:
Article
TARGETING 2 NEUTRAL SPHINGOMYELINASE 2 PROMOTES DEATH OF HIV-INFECTED CELLS.
Published in:
Topics in Antiviral Medicine, 2023, v. 31, n. 2, p. 175
By:
- Seung-Wan Yoo;
- Waheed, Abdul A.;
- Deme, Pragney;
- Rais, Rana;
- Thomas, Ajit;
- Smith, Matthew D.;
- Calabresi, Peter A.;
- Freed, Eric O.;
- Slusher, Barbara S.;
- Haughey, Norman J.
Publication type:
Article
Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain.
Published in:
Neurochemical Research, 2020, v. 45, n. 6, p. 1256, doi. 10.1007/s11064-019-02909-y
By:
- Vornov, James J.;
- Peters, Diane;
- Nedelcovych, Mike;
- Hollinger, Kristen;
- Rais, Rana;
- Slusher, Barbara S.
Publication type:
Article
Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers.
Published in:
Journal of Translational Medicine, 2015, v. 13, n. 1, p. 1, doi. 10.1186/s12967-015-0526-9
By:
- Wozniak, Krystyna M.;
- Vornov, James J.;
- Mistry, Bipin M.;
- Ying Wu;
- Rais, Rana;
- Slusher, Barbara S.
Publication type:
Article
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Published in:
Nephrology Dialysis Transplantation, 2020, v. 35, n. 10, p. 1824, doi. 10.1093/ndt/gfz109
By:
- Soomro, Irfana;
- Sun, Ying;
- Li, Zhai;
- Diggs, Lonnette;
- Hatzivassiliou, Georgia;
- Thomas, Ajit G;
- Rais, Rana;
- Parker, Seth J;
- Slusher, Barbara S;
- Kimmelman, Alec C;
- Somlo, Stefan;
- Skolnik, Edward Y
Publication type:
Article
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Published in:
Nephrology Dialysis Transplantation, 2018, v. 33, n. 8, p. 1343, doi. 10.1093/ndt/gfx349
By:
- Soomro, Irfana;
- Sun, Ying;
- Li, Zhai;
- Diggs, Lonnette;
- Hatzivassiliou, Georgia;
- Thomas, Ajit G;
- Rais, Rana;
- Slusher, Barbara S;
- Somlo, Stefan;
- Skolnik, Edward Y
Publication type:
Article
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model.
Published in:
Translational Neurodegeneration, 2023, v. 12, n. 1, p. 1, doi. 10.1186/s40035-023-00383-9
By:
- Tallon, Carolyn;
- Bell, Benjamin J.;
- Malvankar, Medhinee M.;
- Deme, Pragney;
- Nogueras-Ortiz, Carlos;
- Eren, Erden;
- Thomas, Ajit G.;
- Hollinger, Kristen R.;
- Pal, Arindom;
- Mustapic, Maja;
- Huang, Meixiang;
- Coleman, Kaleem;
- Joe, Tawnjerae R.;
- Rais, Rana;
- Haughey, Norman J.;
- Kapogiannis, Dimitrios;
- Slusher, Barbara S.
Publication type:
Article
Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect.
Published in:
2016
By:
- Rojas, Camilo;
- Alt, Jesse;
- Ator, Nancy A.;
- Wilmoth, Heather;
- Rais, Rana;
- Hin, Niyada;
- DeVivo, Michael;
- Popiolek, Michael;
- Tsukamoto, Takashi;
- Slusher, Barbara S.
Publication type:
journal article
A Novel Oral Glutamate Carboxypeptidase II Inhibitor for the Treatment of Inflammatory Bowel Disease.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3089
By:
- Pradhan, Manisha;
- Peters, Diane E.;
- Norris, Lauren D.;
- Thomas, Ajit G.;
- Rais, Rana;
- Slusher, Barbara S.
Publication type:
Article
A role for mast cells in geographic atrophy.
Published in:
FASEB Journal, 2020, v. 34, n. 8, p. 10117, doi. 10.1096/fj.202000807R
By:
- Ogura, Shuntaro;
- Baldeosingh, Rajkumar;
- Bhutto, Imran A.;
- Kambhampati, Siva P.;
- Scott McLeod, Donald;
- Edwards, Malia M.;
- Rais, Rana;
- Schubert, William;
- Lutty, Gerard A.
Publication type:
Article
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Published in:
2020
By:
- Min-Hee Oh;
- Im-Hong Sun;
- Liang Zhao;
- Leone, Robert D.;
- Im-Meng Sun;
- Wei Xu;
- Collins, Samuel L.;
- Tam, Ada J.;
- Blosser, Richard L.;
- Patel, Chirag H.;
- Englert, Judson M.;
- Arwood, Matthew L.;
- Jiayu Wen;
- Yee Chan-Li;
- Tenora,, Lukáš;
- Majer, Pavel;
- Rais, Rana;
- Slusher, Barbara S.;
- Horton, Maureen R.;
- Powell, Jonathan D.
Publication type:
journal article
EFFECT OF SPRAYING WITH HUMIC ACID AND NANO ZINC ON THE GROWTH AND YIELD OF MATRICARIA CHAMOMILLA L.
Published in:
International Journal of Agricultural & Statistical Sciences, 2022, v. 18, p. 2355
By:
- Arak, Rana Rais
Publication type:
Article
Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives.
Published in:
2018
By:
- Dash, Ranjeet Prasad;
- Rais, Rana;
- Srinivas, Nuggehally R.
Publication type:
journal article
Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice.
Published in:
Pharmaceutics, 2023, v. 15, n. 9, p. 2364, doi. 10.3390/pharmaceutics15092364
By:
- Huang, Meixiang;
- Tallon, Carolyn;
- Zhu, Xiaolei;
- Huizar, Kaitlyn D. J.;
- Picciolini, Silvia;
- Thomas, Ajit G.;
- Tenora, Lukas;
- Liyanage, Wathsala;
- Rodà, Francesca;
- Gualerzi, Alice;
- Kannan, Rangaramanujam M.;
- Bedoni, Marzia;
- Rais, Rana;
- Slusher, Barbara S.
Publication type:
Article
Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice.
Published in:
Pharmaceutics, 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/pharmaceutics14102066
By:
- Tallon, Carolyn;
- Bell, Benjamin J.;
- Sharma, Anjali;
- Pal, Arindom;
- Malvankar, Medhinee M.;
- Thomas, Ajit G.;
- Yoo, Seung-Wan;
- Hollinger, Kristen R.;
- Coleman, Kaleem;
- Wilkinson, Elizabeth L.;
- Kannan, Sujatha;
- Haughey, Norman J.;
- Kannan, Rangaramanujam M.;
- Rais, Rana;
- Slusher, Barbara S.
Publication type:
Article
D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II.
Published in:
Pharmaceutics, 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/pharmaceutics14102018
By:
- Gori, Sadakatali S.;
- Thomas, Ajit G.;
- Pal, Arindom;
- Wiseman, Robyn;
- Ferraris, Dana V.;
- Gao, Run-duo;
- Wu, Ying;
- Alt, Jesse;
- Tsukamoto, Takashi;
- Slusher, Barbara S.;
- Rais, Rana
Publication type:
Article
DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence.
Published in:
2020
By:
- Cuesta, Santiago;
- Restrepo‐Lozano, José Maria;
- Popescu, Christina;
- He, Susan;
- Reynolds, Lauren M.;
- Israel, Sonia;
- Hernandez, Giovanni;
- Rais, Rana;
- Slusher, Barbara S.;
- Flores, Cecilia;
- Restrepo-Lozano, José Maria
Publication type:
journal article
Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0131861
By:
- Rais, Rana;
- Wozniak, Krystyna;
- Wu, Ying;
- Niwa, Minae;
- Stathis, Marigo;
- Alt, Jesse;
- Giroux, Marc;
- Sawa, Akira;
- Rojas, Camilo;
- Slusher, Barbara S.
Publication type:
Article

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