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- Title
Cryoglobulinaemia and rapidly deteriorating renal function in chronic lymphocytic leukaemia.
- Authors
Purhonen, Anna-Kaisa; Mikkola, Maija; Karjalainen, Leena; Helle, Markku; Lumiaho, Anne; Juutilainen, Auni
- Abstract
Cryoglobulinaemia is a rare condition characterized by serum immunoglobulins or immunocomplexes which precipitate at temperatures below 37°C and redissolve on warming. Cryoglobulinaemic vasculitis develops in ~ 15% of patients positive for cryoglobulin serology and is often associated with an underlying infectious, autoimmune or lymphoproliferative disease. We describe a case of cryoglobulinaemic vasculitis, which manifested as purpura and rapidly deteriorating renal function in a patient with chronic lymphocytic leukaemia and coexistent parvovirus infection. This case illustrates the complex pathophysiology of cryoglobulinaemic renal injury, and suggests that infection may serve as a trigger in the presence of other pathophysiological factors.
- Subjects
CHRONIC kidney failure; CHRONIC lymphocytic leukemia; CRYOGLOBULINEMIA; IMMUNOGLOBULINS; TEMPERATURE effect; VASCULITIS; AUTOIMMUNE diseases
- Publication
Nephrology Dialysis Transplantation, 2011, Vol 26, Issue 3, p1101
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfq701