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- Title
The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults.
- Authors
Artifoni, Lina; Benetti, Elisa; Centi, Sonia; Negrisolo, Susanna; Ghiggeri, Gian Marco; Ginevri, Fabrizio; Ghio, Luciana; Edefonti, Alberto; Brambilla, Caterina; Cagni, Nicoletta; Murer, Luisa
- Abstract
Background. The main cause of reduced long-term graft survival is chronic allograft injury. Cardiovascular risk factors such as hyperhomocysteinaemia, accumulation of asymmetric dimethylarginine, increased oxidative stress and decreased production of nitric oxide seem to play an important role. Functional polymorphisms of the endothelial isoform of nitric oxide synthase (NOS) gene cause an alteration in nitric oxide production. Nitric oxide levels, and thus oxidative stress, are also influenced by hyperhomocysteinaemia.
- Subjects
HOMOGRAFTS; KIDNEY diseases; GENETIC polymorphisms; KIDNEY transplantation; NITRIC oxide; OXIDATIVE stress; HOMOCYSTEINE; PEDIATRIC nephrology
- Publication
Nephrology Dialysis Transplantation, 2009, Vol 24, Issue 9, p2931
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfp161