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- Title
Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target.
- Authors
Karmazyn, Morris
- Abstract
The myocardial sodium-hydrogen exchanger (NHE), and more specifically the NHE-1 isoform is now well-recognized to be a major contributor to ischemic and reperfusion injury. Recent evidence suggests that NHE-1 is also potential candidate for targeted intervention in terms of attenuation of the remodelling and hypertrophic processes which contributes to heart failure. Experimental studies have shown that NHE-1 inhibitors attenuate cardiomyocyte hypertrophy induced by various factors and reduce heart failure in vivo, independently of infarct size reduction. Although the precise cellular mechanisms for NHE-1 involvement remain to be elucidated, current data suggest a potentially effective new therapeutic approach for the treatment of heart failure via NHE-1 inhibition.
- Subjects
CARDIAC hypertrophy; ISCHEMIA; REPERFUSION injury; HEART failure; CARDIAC arrest; HEART diseases
- Publication
Basic Research in Cardiology, 2001, Vol 96, Issue 4, p325
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950170040