We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
İnsan Hastalıklarında Endotel Fonksiyon ve ID Disfonksiyonunun Moleküler Mekanizmaları.
- Authors
Günel, Tuba; Çelik, Hale Göksever; Küçükkaya, Reyhan Diz; Alkaç, İsmail Mert; Aydınlı, Kılıç
- Abstract
The vascular endothelium is an important organ that covers all of the inner surface of blood vessels and regulates several important physiological and pathological reactions. As a barrier, the endothelium regulates the transfer of molecules and acts like a semipermeable layer. They retain the capacity to rapidly initiate new vessel formation in response to injury or pathological conditions. Angiogenesis is the process of formation of new vessels from existing vessels to provide oxygen and nutrients to tissues. Blood vessels , and their components have a critical importance for hemostasis, thrombosis, and inflamation. Angiogenesis is a complex process in which strictly regulated multiple cell types are involved. Several mediators are involved in this process including nitric oxide (NO endothelium-derived relaxing factor), prostacyclin (PG12) which ensure vasodilatation, endothelin 1, platelet- activating factor and angiotensin II that induce vasoconstriction. Endothelial dysfunction (ED) is a pathological condition caused by the imbalance between vasodilation and vasoconstriction provided by the endothelium. Endothelial dysfunction is transformed into pathological functions which will result in unfavourable outcomes. Endothelial dysfunction plays a role in the pathogenesis of a variety of diseases such as hypertension, coronary artery disease, chronic heart failure, peripheral artery disease, diabetes, cancer and preeclampsia. Differences in normal and dysfunctional endothelium may present new therapeutic possibilities for improved antiangiogenesis. This review is written to describe the functions endothelial cells, mediators and signaling pathways in all stages of major diseases and relevant treatment tips.
- Publication
Medical Journal of Istanbul Kanuni Sultan Süleyman / İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 2020, Vol 12, Issue 3, p201
- ISSN
2148-273X
- Publication type
Article
- DOI
10.5222/iksstd.2020.61587