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- Title
© A MURINE MODEL FOR ASSESSMENT OF LIVING ATTENUATED INFLUENZA A VACCINES.
- Authors
Wark, Margaret C.; Tannock, Gregory A.; Sutherland, Megan M.; Smith, Linda E.
- Abstract
The article discusses a murine model for assessment of living attenuated influenza A vaccines. The immunity produced from respiratory infection by influenza A viruses is considered to produce more effective resistance to subsequent reinfection than that afforded by parenteral vaccination. Ts and ca mutants of influenza A have been developed to provide this immunity by undergoing limited and relatively asymptomatic multiplication in the upper human respiratory tract but not the lower. The findings suggest that the laboratory mouse is at least as sensitive an index of reversion as the hamster.
- Subjects
INFLUENZA vaccines; RESPIRATORY infections; DISEASE relapse; INFLUENZA prevention; INFLUENZA viruses; RESPIRATORY diseases
- Publication
Australian Journal of Experimental Biology & Medical Science, 1980, Vol 58, Issue 6, p615
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1980.64