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- Title
The Birth of Morphomechanics.
- Authors
Ermakov, A. S.
- Abstract
At the early 1970s, in the USSR, L.V. Beloussov and his colleagues from Moscow State University put forward a hypothesis about the possible role of mechanical forces and stresses in the organization of developing living systems. The authors discovered stage-specific patterns of mechanical stresses during amphibian embryonic development and showed that mechanical stresses are necessary for the organization of morphogenesis and cellular differentiation. As a result of the long-term work of Moscow embryologists, morphomechanics, new interdisciplinary science at the intersection of developmental biology and mechanics, was born. In the 21st century, mechanisms of mechano-dependent gene expression, cellular and nuclear mechanotransduction are intensively studied. The idea of the organizing role of mechanical forces and stresses in living systems remains very relevant.
- Subjects
SOVIET Union; MOSCOW (Russia); MOSCOW State University; STRAINS &; stresses (Mechanics); MECHANOTRANSDUCTION (Cytology); DEVELOPMENTAL biology; EMBRYOLOGY; GENE expression
- Publication
Russian Journal of Developmental Biology, 2023, Vol 54, Issue 4, p240
- ISSN
1062-3604
- Publication type
Article
- DOI
10.1134/S1062360423040033