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- Title
Glycobiology of Cancer: Sugar Drives the Show.
- Authors
Santos dos Reis, Jhenifer; Rodrigues da Costa Santos, Marcos André; Pereira Mendonça, Daniella; Martins do Nascimento, Stefani Ingrid; Marçal Barcelos, Pedro; Correia de Lima, Rafaela Gomes; Monteiro da Costa, Kelli; Geraldo Freire-de-Lima, Celio; Morrot, Alexandre; Osvaldo Previato, Jose; Mendonça Previato, Lucia; Marques da Fonseca, Leonardo; Freire-de-Lima, Leonardo
- Abstract
Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression.
- Subjects
GLYCOMICS; CANCER treatment; GLYCOSYLATION; GLYCOSYLTRANSFERASES; IMMUNE response
- Publication
Medicines, 2022, Vol 9, Issue 6, p1
- ISSN
2305-6320
- Publication type
Article
- DOI
10.3390/medicines9060034