We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
White matter microstructure disruption in early stage amyloid pathology.
- Authors
Collij, Lyduine E.; Ingala, Silvia; Top, Herwin; Wottschel, Viktor; Stickney, Kristine E.; Tomassen, Jori; Konijnenberg, Elles; Kate, Mara ten; Sudre, Carole; Alves, Isadora Lopes; Yaqub, Maqsood M.; MeijeWink, Alle; Van ‘t Ent, Dennis; Scheltens, Philip; van Berckel, Bart N. M.; Visser, Pieter Jelle; Barkhof, Frederik; Braber, Anouk Den
- Abstract
Introduction: Amyloid beta (Aβ) accumulation is the first pathological hallmark of Alzheimer’s disease (AD), and it is associated with altered white matter (WM) microstructure. We aimed to investigate this relationship at a regional level in a cognitively unimpaired cohort. Methods:We included 179 individuals from the European Medical Information Framework for AD (EMIF-AD) preclinAD study, who underwent diffusion magnetic resonance (MR) to determine tract-level fractional anisotropy (FA); mean, radial, and axial diffusivity (MD/RD/AxD); and dynamic [18F]flutemetamol) positron emission tomography (PET) imaging to assess amyloid burden. Results: Regression analyses showed a non-linear relationship between regional amyloid burden and WM microstructure. Low amyloid burden was associated with increased FA and decreased MD/RD/AxD, followed by decreased FA and increased MD/RD/AxD upon higher amyloid burden. The strongest association was observed between amyloid burden in the precuneus and body of the corpus callosum (CC) FA and diffusivity (MD/RD) measures. In addition, amyloid burden in the anterior cingulate cortex strongly related to AxD and RD measures in the genu CC. Discussion: Early amyloid deposition is associated with changes in WM microstructure. The non-linear relationship might reflect multiple stages of axonal damage.
- Subjects
AMYLOID beta-protein; ALZHEIMER'S disease; WHITE matter (Nerve tissue); MAGNETIC resonance imaging; EMISSION-computed tomography; CORPUS callosum
- Publication
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021, Vol 13, Issue 1, p1
- ISSN
2352-8729
- Publication type
Article
- DOI
10.1002/dad2.12124