We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Redox-Mediated Rewiring of Signalling Pathways: The Role of a Cellular Clock in Brain Health and Disease.
- Authors
Vujovic, Filip; Shepherd, Claire E.; Witting, Paul K.; Hunter, Neil; Farahani, Ramin M.
- Abstract
Metazoan signalling pathways can be rewired to dampen or amplify the rate of events, such as those that occur in development and aging. Given that a linear network topology restricts the capacity to rewire signalling pathways, such scalability of the pace of biological events suggests the existence of programmable non-linear elements in the underlying signalling pathways. Here, we review the network topology of key signalling pathways with a focus on redox-sensitive proteins, including PTEN and Ras GTPase, that reshape the connectivity profile of signalling pathways in response to an altered redox state. While this network-level impact of redox is achieved by the modulation of individual redox-sensitive proteins, it is the population by these proteins of critical nodes in a network topology of signal transduction pathways that amplifies the impact of redox-mediated reprogramming. We propose that redox-mediated rewiring is essential to regulate the rate of transmission of biological signals, giving rise to a programmable cellular clock that orchestrates the pace of biological phenomena such as development and aging. We further review the evidence that an aberrant redox-mediated modulation of output of the cellular clock contributes to the emergence of pathological conditions affecting the human brain.
- Subjects
CELLULAR signal transduction; BRAIN diseases; RAS proteins; PHENOMENOLOGICAL biology; MOLECULAR clock
- Publication
Antioxidants, 2023, Vol 12, Issue 10, p1873
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox12101873