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- Title
Shedding Light on the Hidden Benefit of Porphyridium cruentum Culture.
- Authors
Liberti, Davide; Imbimbo, Paola; Giustino, Enrica; D'Elia, Luigi; Silva, Mélanie; Barreira, Luísa; Monti, Daria Maria
- Abstract
Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.
- Subjects
ANTI-inflammatory agents; EUKARYOTIC cells; CELL lines; MICROALGAE; BIOCOMPATIBILITY
- Publication
Antioxidants, 2023, Vol 12, Issue 2, p337
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox12020337