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- Title
人胚静脉窦与心背侧间充质突的形成与重塑.
- Authors
杨艳萍; 李海荣; 曹锡梅; 景雅; 崔慧林; 张涛
- Abstract
BACKGROUND: Formation and remodeling of sinus venosus and the function of the dorsal mesenchymal protrusion (DMP) in human embryonic heart remain controversial. OBJECTIVE: To explore the function of DMP and the sinus venosus development in the process of human embryo atrial separation. METHODS: The human embryos were fixed for 24 hours immediately after harvesting, followed by staged based on Carnegie stage (CS10-CS17) under stereo microscope. Serial sections of human embryos were stained immunohistochemically. RESULTS AND CONCLUSION: During CS10-CS12, the isl1 positive cells of the pharyngeal ventral mesenchyme and the dorsal pericardial wall extended to the sinus venosus wall to contribute to myocardium formation. From CS13, isl1 began to express in the coronary sinus and the caval vein wall and these blood vessels began to be myocardialized. Meanwhile, the isl1 positive cells participated in the formation of DMP. At CS15, the DMP contributed to the atrial separation and was myocardialized gradually. These data suggest that in human embryo, the sinus venosus is formed and the myocardium of the venous tributaries is derived from the isl1 positive cells of second heart field. The formation and function of the DMP in human embryo are similar to those of the mouse embryo.
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2018, Vol 22, Issue 20, p3130
- ISSN
2095-4344
- Publication type
Article
- DOI
10.3969/j.issn.2095-4344.0293