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- Title
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines.
- Authors
Smith, Michael W.; O'Brien, Stephen J.
- Abstract
Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200–500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.
- Subjects
GENE mapping; HUMAN genetic variation; ETHNIC groups; HUMAN gene mapping; GENETIC techniques
- Publication
Nature Reviews Genetics, 2005, Vol 6, Issue 8, p623
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg1657