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- Title
Q ABSORBANCE RATIO METHOD FOR SIMULTANEOUS ESTIMATION OF AMOXICILLIN AND PROBENECID IN TABLET DOSAGE FORM.
- Authors
Shah, Dhwani; Vegad, Kunjal; Patel, Ekta; Prajapati, Jigna; Patel, Kaushik; Patel, Yogesh
- Abstract
A simple, accurate, rapid, economical UV spectrophotometry method namely Absorption ratio, and RP-HPLC method have been developed and validated for estimation of Amoxicillin and Probenecid in combined tablet dosage form and can be used in routine analysis. In Absorbance ratio method absorbance measured 228nm and at Iso-absorptive point 237 and correlation coefficient was found to be 0.9971,0.9968 and 0.998,0.998 for Amoxicillin and Probenecid at 228nm and 237nm respectively. Mean assay was found to be 99.51251% and 98.93545% for Amoxicillin and Probenecid respectively by Absorption ratio method. Both the methods were found to be linear in the concentration range of 2-14µg/ml for Amoxicillin and 2-14µg/ml for Probenecid.
- Subjects
AMOXICILLIN; DOSAGE forms of drugs; ULTRAVIOLET spectrophotometry
- Publication
International Journal of Chemical & Pharmaceutical Analysis, 2017, Vol 4, Issue 4, p1
- ISSN
2348-0726
- Publication type
Article
- DOI
10.21276/ijcpa