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- Title
The Significance of Serum SCCA and MMPs in Determining Cervical Cancer Progression.
- Authors
DUAN Jing; DUAN Zhao
- Abstract
Objective To study the significance of serum SCCA and MMPs in determining cervical cancer progression. Methods One hundred and three cases of cervical squamous cell carcinoma patients were enrolled (40 cases of stage 1,51 cases of stage H , 12 cases of stage H) , while 40 cases of healthy women were selected as a control group. Results The levels of SCCA and CA125 in patients of stage I were significantly higher than those in control group (P< 0.05) . Compared with the stage I and control groups, SCCA levels have significantly increased in patients of stage H (P< 0.05) , and CA125 levels were significantly higher in stage H patients than the control group patients (P < 0.05) . Compared with the other three groups, SCCA levels in stage H were significantly increased (P< 0.05) , and CA125 levels in stage H were significantly higher than those in the control group and stage I (P< 0.05) . MMP-9 levels in stage I and H patients was significantly higher than those in the control group (P< 0.05) . Compared with the control and stage I groups, MMP-9 and TIMP-1 showed significant differences (P<0.05), among which TIMP-1 was significantly decreased (P<0.05) . MMP-3 and MMP-9 in stage H have significantly increased in comparison with the other three groups ( P < 0.05) . SCCA showed ignificant positive correlations with MMP-3 and MMP-9 (P < 0.05) and a significant negative correlation with TIMP (P<0.05) . CA125 showed a significant positive correlation with MMP-9 (P < 0.05) . Conclusion Staging of cervical cancer is closely related to MMPs disorder. Combining the SCCA and other indicators could help to determine the progress of the disease.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p94
- ISSN
2095-610X
- Publication type
Article