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- Title
Hypertriglyceridemic waist phenotype is associated with decreased insulin sensitivity and incident diabetes in elderly men.
- Authors
Carlsson, Axel C.; Risérus, Ulf; Ärnlöv, Johan
- Abstract
Objective: To investigate the association between hypertriglyceridemic waist (HTGW) and insulin sensitivity (assessed by euglycemic clamp method), and the development of diabetes in a longitudinal community-based cohort of elderly men without diabetes at baseline. Design and Methods: The present cross-sectional study comprised 1,026, 70-year-old men without diabetes. The gold standard euglycaemic-hyperinsulinaemic clamp technique was used. Six-year follow-up on diabetes status were available in n = 667. The HTGW phenotype was defined as having waist circumference ≥ 90 cm, and triglycerides ≥ 2 mmol L−1. The men were stratified into those having normal WC and TG ( n = 299), one HTGW component ( n = 606), and HTGW ( n = 121). Results: The association between insulin sensitivity and one HTGW component as well as HTGW was highly significant ( P < 0.001) in the whole sample, as well as in individuals with high/low BMI (stratified at ≥25). In longitudinal analyses, participants with HTGW was associated with a more than fourfold increased risk for diabetes (Odds ratio 4.64, 95% CI 1.61-13.4, P = 0.004) compared to those with normal WC and TG. Conclusion: The present study both confirm and extend previous research suggesting that the HTGW-phenotype portrays an increased glucometabolic risk, also in lean individuals.
- Subjects
HYPERTRIGLYCERIDEMIA; HYPERLIPIDEMIA; INSULIN resistance; DIABETES complications; PHENOTYPES
- Publication
Obesity (19307381), 2014, Vol 22, Issue 2, p526
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1002/oby.20434