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- Title
Antioxidant and In Vivo Hypoglycemic Activities of Ethanol Extract from the Leaves of Engelhardia roxburghiana Wall, a Comparative Study of the Extract and Astilbin.
- Authors
Guo, Xiaoqiang; Zhou, Ting; Xing, Hongxia; Zhang, Yucheng; Fang, Jingmei; Kang, Tairan; Yao, Caimei; Yan, Jun; Huang, Yaxuan; Yao, Qian
- Abstract
The leaves of Engelhardia roxburghiana Wall (LERW) has been used as sweet tea in China throughout history. In this study, the ethanol extract of LERW (E-LERW) was prepared and the compositions were identified by HPLC-MS/MS. It indicates that astilbin was the predominant component in E-LERW. In addition, E-LERW was abundant in polyphenols. Compared to astilbin, E-LERW presented much more powerful antioxidant activity. The E-LERW also had stronger affinity with α-glucosidase and exerted more vigorous inhibitory effect on the enzyme. Alloxan-induced diabetic mice had significantly elevated glucose and lipid levels. Treatment with E-LERW at the medium dose (M) of 300 mg/kg could reduce the levels of glucose, TG, TC, and LDL by 16.64%, 12.87%, 32.70%, and 22.99%, respectively. In addition, E-LERW (M) decreased food intake, water intake, and excretion by 27.29%, 36.15%, and 30.93%, respectively. Moreover, E-LERW (M) therapy increased the mouse weight and insulin secretion by 25.30% and 494.52%. With respect to the astilbin control, E-LERW was more efficient in reducing the food and drink consumption and protecting pancreatic islet and body organs from alloxan-induced damage. The study demonstrates that E-LERW may be a promising functional ingredient for the adjuvant therapy of diabetes.
- Subjects
CHINA; ETHANOL; DRINKING (Physiology); ICED tea; ISLANDS of Langerhans; ORGANS (Anatomy); CHINESE history
- Publication
Foods, 2023, Vol 12, Issue 5, p927
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods12050927