We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Overexpression of microRNA-130a predicts adverse prognosis of primary gastrointestinal diffuse large B-cell lymphoma.
- Authors
Chen, Leiyuan; Kan, Yutian; Wang, Xinyuan; Ge, Peng; Ding, Tingting; Zhai, Qiongli; Wang, Yafei; Yu, Yong; Wang, Xiaofang; Zhao, Zhigang; Yang, Hongliang; Liu, Xianming; Li, Lanfang; Qiu, Lihua; Zhang, Huilai; Qian, Zhengzi; Zhao, Haifeng
- Abstract
Primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) is a highly heterogeneous type of non-Hodgkin lymphoma. A number of studies have demonstrated that microRNA-130a (miR-130a) serves a role in the tumorigenesis and prognosis of numerous human tumors. However, to the best of our knowledge, the prognostic significance of miR-130a in PGI-DLBCL remains unknown. The present study explored the association between miR-130a and the clinical outcomes of PGI-DLBCL. Relative miR-130a expression was assessed by reverse transcription-quantitative PCR. Immunohistochemistry was used to detect expression levels of BCL-2, c-MYC, neprilysin, B-cell lymphoma 6 protein, PWWP domain-containing DNA repair factor 3A and proliferation marker protein Ki-67. A receiver operating characteristic curve was constructed to analyze the specificity and sensitivity of microRNA levels in the diagnosis of PGI-DLBCL. Survival curves were constructed using the Kaplan-Meier method. In the present study, miR-130a expression was notably higher in patients with PGI-DLBCL compared with in the controls (P<0.0001). miR-130a overexpression was closely associated with a high International Prognostic Index score (3–5) and drug resistance (P=0.017 and P=0.044, respectively). No significant difference in other clinical features was observed. Patients with increased expression levels of miR-130a had lower overall survival [hazard ratio (HR), 2.998; 95% CI, 1.347-6.673; P=0.007] and progression-free survival (HR, 3.325; 95% CI, 1.488-7.429; P=0.003) compared with patients who had lower expression levels of miR-130a. Furthermore, multivariate Cox regression analysis suggested that miR-130a was a negative prognostic parameter in PGI-DLBCL. Therefore, upregulation of miR-130a could become a potential prognostic marker for PGI-DLBCL. Additionally, further study of these results may have important guiding significance for the prognosis of patients with PGI-DLBCL in the clinical setting.
- Subjects
DIFFUSE large B-cell lymphomas; RECEIVER operating characteristic curves; PROGRESSION-free survival; PROGNOSIS; DNA repair; REGRESSION analysis
- Publication
Oncology Letters, 2020, Vol 20, Issue 4, pN.PAG
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.11954