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- Title
Isocaloric replacement of ultraprocessed foods was associated with greater weight loss in the POUNDS Lost trial.
- Authors
Yao, Qisi; de Araujo, Carolina D.; Juul, Filippa; Champagne, Catherine M.; Bray, George A.; Sacks, Frank M.; Vadiveloo, Maya K.
- Abstract
Objective: Higher intake of ultraprocessed foods (UPFs) is associated with obesity. We examined whether replacing UPFs (NOVA 4) with minimally processed foods and culinary ingredients (NOVA 1 + 2) was associated with differential weight change in this secondary prospective analysis of the Preventing Overweight Using Novel Dietary Strategies (POUNDS) Lost trial. Methods: We estimated percent energy intake (%kcal) from the four NOVA groups using 24‐h dietary recalls in a subset of 356 participants. Multivariable‐adjusted substitution models examined whether replacing %kcal from UPFs with NOVA 1 + 2 was associated with greater weight, body fat percentage, trunk fat, and waist circumference reduction at 6 months; changes in parameters were compared among NOVA 1 + 2 tertiles (T). Results: Participants were on average 52.3 years of age, 85% White, 55% female, and 58.2% nonsmoking, with a mean BMI of 32.7 kg/m2. Replacing 10%kcal of UPFs with NOVA 1 + 2 was associated with greater 6‐month weight (ß = 0.51, 95% CI: −0.93 to −0.09, p = 0.02), body fat percentage (ß = 2.7, 95% CI: −5.10 to −0.43, p = 0.02), and trunk fat reduction (ß = 3.9, 95% CI: −7.01 to −0.70, p = 0.02), but not waist circumference reduction. Participants in T3 (−8.33 kg) versus T1 (−5.32 kg) of NOVA 1 + 2 had greater weight loss (p < 0.001). Conclusions: Isocaloric substitution of UPFs with NOVA 1 + 2 was associated with marginally greater weight loss under energy restriction. These modest findings support more research exploring the mechanisms linking UPFs with body weight regulation beyond energy intake.
- Subjects
WEIGHT loss; REGULATION of body weight; WAIST circumference; FAT; ENERGY dissipation
- Publication
Obesity (19307381), 2024, Vol 32, Issue 7, p1281
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1002/oby.24044