We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prospective Study of Long-Term Interrelationships Among Adiposity-Associated Biomarkers in Women.
- Authors
Baden, Megu Y.; Hu, Frank B.; Huang, Tianyi
- Abstract
<bold>Objective: </bold>This study aimed to investigate the prospective interrelationships among biomarkers that may provide mechanistic insights into obesity-related diseases.<bold>Methods: </bold>A total of 850 women in the Nurses' Health Study II with two fasting blood measurements (1996-1999 and 2010-2011) of adiponectin, leptin, soluble leptin receptor, insulin, retinol-binding protein 4, high-sensitivity C-reactive protein (hsCRP), and interleukin-6 were included. Biomarker interrelationships were examined in the following three ways: (1) cross-sectional associations at baseline and follow-up, (2) longitudinal associations of concurrent biomarker changes, and (3) prospective associations of each baseline biomarker with other biomarker changes.<bold>Results: </bold>In cross-sectional analyses, most biomarkers were correlated after multivariable adjustment including BMI, with the strongest correlations observed between leptin and insulin and between hsCRP and interleukin-6. In longitudinal analyses, similar results were observed after multivariable adjustment including weight change. However, in prospective analyses, only three associations observed in cross-sectional and longitudinal analyses were consistently significant (P < 0.05). Every doubling in baseline adiponectin was associated with -9.0% insulin change. The corresponding estimate was 9.3% for baseline leptin and hsCRP change and 3.1% for baseline hsCRP and leptin change.<bold>Conclusions: </bold>Baseline adiponectin concentrations were inversely associated with subsequent insulin change, whereas baseline leptin concentrations were positively associated with hsCRP change and vice versa.
- Subjects
RETINOL-binding proteins; LONGITUDINAL method; LEPTIN receptors; BIOMARKERS; LEPTIN; ADIPOSE tissue physiology; OBESITY; INTERLEUKINS; C-reactive protein; RESEARCH; TIME; CROSS-sectional method; RESEARCH methodology; CELL receptors; EVALUATION research; MEDICAL cooperation; INSULIN; SEX distribution; COMPARATIVE studies; ADIPONECTIN; BLOOD
- Publication
Obesity (19307381), 2020, Vol 28, Issue 2, p452
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22706