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- Title
Outcomes and patterns of treatment in chronic myeloid leukemia, a global perspective based on a real-world data global network.
- Authors
Sanz, A.; Ayala, R.; Hernández, G.; Lopez, N.; Gil-Alos, D.; Gil, R.; Colmenares, R.; Carreño-Tarragona, G.; Sánchez-Pina, J.; Alonso, R. A.; García-Barrio, N.; Pérez-Rey, D.; Meloni, L.; Calbacho, M.; Cruz-Rojo, J.; Pedrera-Jiménez, M.; Serrano-Balazote, P.; de la Cruz, J.; Martínez-López, J.
- Abstract
In the H12O cohort, 32 patients from each cohort were compared, with two deaths in the CML cohort and 5 in the non-oncology patients ( I p i = 0-23). The U.S. cohort also showed slightly better survival in non-oncologic patients but without statistical significance, 284 deaths out of 1852 CML patients versus 251 deaths out of 1852 non-oncologic patients, with an HR 1-095 (0-92-1-29), I p i = 0-295 (Supplementary Fig. In the U.S. cohorts, out of 5249 patients, 3380 (64-4%) CML patients developed a second malignancy, compared to only 902 (17.2%, I p i < 0-001) of the non-CML cohort (OR 8-72 with 95% CI (7-96, 9-55)). Thus, the analyses were run on four different patients cohorts to independently confirm our hypotheses: H12O, with around 1,000,000 patients; the EMEA Collaborative Network (EMEA), with 11,000,000 patients from 18 HCOs; the US Collaborative Network (US), with 73,000,000 patients from 47 HCOs, and the Global Collaborative Network (Global), with 90,000,000 patients from 75 HCOs.
- Subjects
CHRONIC myeloid leukemia; CHRONIC leukemia; TREATMENT effectiveness; DATABASES
- Publication
Blood Cancer Journal, 2022, Vol 12, Issue 6, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-022-00692-8