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- Title
The Apelin/APJ System in Psychosis and Neuropathy.
- Authors
Lv, Shuang-Yu; Chen, Wei-Dong; Wang, Yan-Dong
- Abstract
Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy.
- Subjects
APELIN; PERIPHERAL nervous system; NEUROPATHY; MESSENGER RNA; CENTRAL nervous system; NEUROPEPTIDES
- Publication
Frontiers in Pharmacology, 2020, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2020.00320