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- Title
The transient receptor potential vanilloid‐3 (TRPV3) channel in epidermal keratinocytes induce thymic interstitial lymphopoietin: Implications for TRPV3‐mediated itch pathways.
- Authors
Um, Ji Young; Kim, Han Bi; Shim, Won‐Sik; Lee, Wook Joo; Lee, So Yeon; Park, Jin Seo; Kim, Jin Cheol; Kwak, In Suk; Chung, Bo Young; Park, Chun Wook; Kim, Hye One
- Abstract
This article discusses the role of the transient receptor potential vanilloid-3 (TRPV3) channel in inducing thymic interstitial lymphopoietin (TSLP) and its implications for itch pathways. The study found that TRPV3 activation regulates TSLP expression through calcium influx and the calcineurin/NFAT/NF-kB pathway. Carvacrol, a compound that activates TRPV3, was shown to increase TSLP and calcium influx, suggesting its involvement in TRPV3-mediated itch pathways. The findings provide insights into the molecular mechanisms of chronic pruritus and potential therapeutic targets for inflammatory skin diseases.
- Subjects
ITCHING; CARVACROL; TRPV cation channels; TRP channels; KERATINOCYTES
- Publication
Clinical & Experimental Allergy, 2024, Vol 54, Issue 2, p152
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.14426