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- Title
Intranasal delivery of rapid-onset antidepressants: a new trend of treating major depressive disorder.
- Authors
Yuqi Xie; Yushun Dou; Yue Tang
- Abstract
Existing antidepressants seem to have an onset time of several weeks. However, newly found depression-related receptors and pathwsys may enlighten us to find more rapid-onset antidepressants, inwhich ketamine is one of the most potential antidepressants. By inkanasal administration drugs can be directly delivered to the brain via olfactory nerve route, which is proved to be suitable for some anti depressants Well- designed rapid- onset antidepressants are the urgent requirements of the patients with depression. Intranasal administration as a potential strategy to deliver antidepressants to braiix can improve drug efficacy and largely shorten the onset time. In this article,we sorted out some new formulation 呼)pro aches in treating depression with different mechanisms and pathways compared with traditional treating stxateges, along with new findings in clinical studies, proving that the combination of rapid-onset antidepressants with intranasal delivery will lead a new trend in treating depression.
- Subjects
ANTIDEPRESSANTS; MENTAL depression; OLFACTORY nerve; OLFACTORY cortex; DRUG efficacy; DRUG administration
- Publication
Journal of Chinese Pharmaceutical Sciences, 2020, Vol 29, Issue 8, p515
- ISSN
1003-1057
- Publication type
Article
- DOI
10.5246/jcps.2020.08.049