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- Title
Simultaneous engagement of the activatory receptors NKG2D and CD3 for retargeting of effector cells to CD33-positive malignant cells.
- Authors
Stamova, S.; Cartellieri, M.; Feldmann, A.; Bippes, C. C.; Bartsch, H.; Wehner, R.; Schmitz, M.; von Bonin, M.; Bornhäuser, M.; Ehninger, G.; Rieber, E. P.; Bachmann, M.
- Abstract
The article presents a study which describes two novel bi-specific anti CD33 antibody constructs for CD33-positive acute myeloid leukemia (AML) blasts by means of CD3+ and/or NKG2D+ effector cells. CD8 T cells and NKG2D+ that are redirected by the CD3 complex are costimulated by NKG2D receptor pathways. Moreover, the simultaneously targeting pf T- and NK cells are more superior than retargeting single immune effector cells and that both the anti-CD33 antibody are potential for clinical testing.
- Subjects
GENE targeting; ENZYME activation; T cells; CELL differentiation; RECEPTOR antibodies; LECTINS; NUCLEAR receptors (Biochemistry); CLINICAL trials
- Publication
Leukemia (08876924), 2011, Vol 25, Issue 6, p1053
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2011.42