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- Title
Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies.
- Authors
Boers, D.; van Amelsvoort, L.; Colosio, C.; Corsini, E.; Fustinoni, S.; Campo, L.; Bosetti, C.; La Vecchia, C.; Vergieva, T.; Tarkowski, M.; Liesivuori, J.; Steerenberg, P.; van Loveren, H.
- Abstract
We conducted a multicenter prospective study to assess the effects of occupational exposure to ethylenebisdithiocarbamate fungicides and/or other pesticides on self-reported asthma and asthmatic symptoms. This multicenter study was conducted among 248 workers exposed to pesticides and 231 non-exposed workers from five field studies. The five field studies were carried out in The Netherlands, Italy, Finland, and two studies in Bulgaria. Subjects constituting this cohort completed a self-administered questionnaire at baseline (before the start of exposure). Ethylenethiourea in urine was determined to assess exposure to ethylenebisdithiocarbamates. In multivariate analyses adjusted for all potential confounders (age, education, residence, smoking, gender, and field study), we found inverse associations, all not statistically significant, between occupational exposure to pesticides and asthma diagnosis (OR 0.41; 95% CI 0.15-1.11), complains of chest tightness (OR 0.60; 95% CI 0.36-1.02), wheeze (OR 0.56; 95% CI 0.32-0.98), asthma attack (OR 0.52; 95% CI 0.12-2.25), and asthma medication (OR 0.79; 95% CI 0.25-2.53). Furthermore, we reported null associations for multivariate analysis using ethylenethiourea as determinant for exposure. Although exposure to pesticides remains a potential health risk, our results do not suggest an association between exposure to ethylenebisdithiocarbamates and/or other pesticides used in our study on asthma and asthmatic symptoms.
- Subjects
EUROPE; ASTHMA; EBDC (Fungicide); PHYSIOLOGICAL effects of pesticides; RISK assessment of pesticides; PESTICIDE toxicology; EMPLOYEES; MULTIVARIATE analysis
- Publication
Human & Experimental Toxicology, 2008, Vol 27, Issue 9, p721
- ISSN
0960-3271
- Publication type
Article
- DOI
10.1177/0960327108100001