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- Title
The Value of Serum CA19-9 Levels in predicting Extent of Hepatic Fibrosis in Patients with Chronic Hepatitis B.
- Authors
Haque, Mohammad Sayedul; Sultana, Sharmin; Mamun-Al-Mahtab; Al-Mamun, Ayub; Rahman, Salimur
- Abstract
This cross-sectional observational study was conducted to evaluate the implication of CA19-9 level in predicting the extent of hepatic fibrosis in patients with chronic hepatitis B (CHB). Fifty treatment-naïve patients with CHB were divided into three groups: group I, patients with no fibrosis (F0; n = 3); group II, patients with mild fibrosis (F1; n = 25) and group III, patients with moderate fibrosis (F3; n = 22). There was no significant (p > 0.05) difference in levels of serum bilirubin, serum alanine aminotransferase, alkaline phosphatase, and alpha fetoprotein among groups I, II and III. Also, mean CA19-9 level did not differ among the three groups. It was observed that, for group II, AUC was 42.6%, sensitivity 52%, specificity 32%, considering cut-off value as 2.8 U/ml to predict F1 liver fibrosis. For group III, AUC was 57.7%, sensitivity 68%, specificity 50% considering cut-off value as 3.2 U/ml to predict F3 fibrosis. The levels of CA19-9 level do not seem to have significant predictive implication to assess hepatic fibrosis.
- Subjects
HEPATIC fibrosis; LIVER diseases; CHRONIC hepatitis B; CHRONIC diseases; HEPATITIS B
- Publication
Euroasian Journal of Hepato-Gastroenterology, 2015, Vol 5, Issue 1, p16
- ISSN
2231-5047
- Publication type
Article
- DOI
10.5005/jp-journals-10018-1122