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- Title
ULTRASTRUCTURE AND HUMAN PAPILLOMAVIRUS DNA IN PAPILLOMATOSIS OF EXTERNAL AUDITORY CANAL.
- Authors
Ming-Yu Xia; Wen-Yuan Zhu; Jung-Yu Lu; Qin Lu; Lei Chen
- Abstract
<em>Background</em>. A viral etiology has been suspected in papillomatosis of the external auditory canal (PEAC), but virus particles have not been detected so far, although they are easily demonstrable in skin warts. The purpose of the study was to solve this discrepancy by the use of polymerase chain reaction (PCR). <em>Materials and Methods</em>. Specimens from the external auditory canal of 14 patients with PEAC, but no human papilloma virus infection of the genital areas, were examined histologically by light and electron microscopy, as well as by PCR to detect viral DNA. <em>Results</em>. Histologically, papillomatosis was present in all specimens. Vacuolated cells were found in the upper part of the stratum malpighii in five cases. On electron microscopy, the numbers of perichromatin and interchromatin granules were increased, but no viral granules were observed. In all specimens, DNA of HPV 6 was detected using PCR, but there was no evidence of DNA of other HPV. <em>Conclusions</em>. Papilloma of the external auditory canal is produced by infection with HPV 6.
- Subjects
EAR canal; ULTRASTRUCTURE (Biology); SKIN infections; PAPILLOMAVIRUS diseases; DNA; ELECTRON microscopy
- Publication
International Journal of Dermatology, 1996, Vol 35, Issue 5, p337
- ISSN
0011-9059
- Publication type
Report
- DOI
10.1111/j.1365-4362.1996.tb03634.x