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- Title
Musa Sapientum attenuates total antioxidant and lipid profile values in rats with indomethacin-induced gastric ulceration.
- Authors
Akinlolu, Abdulazeez Adelaja; Ghazali, Olaide Kamal; Salau, Bamidele Adewale; Otulana, Jubril Olatoye; Omowunmi, Mobolaji
- Abstract
We investigated anti-ulcer properties of Musa sapientum sucker in rats. Group I was control. Indomethacin (40mg/kg/ bodyweight) was orally administered to rats of Groups II - VI for induction of ulcer. Four hours after administrations of the ulcerogen; 5, 10 and 20mg/kg/bodyweight of Musa sapientum sucker extract and 40mg/kg/bodyweight of Omeprazole were administered orally to rats of Groups III - VI respectively. Analyses of lipid profile status, kidney functions tests and activities of glutathione, superoxide dismutase and catalase in the serum and stomach samples of rats of Group II showed statistically significant higher activities (P0.05) of antioxidant enzymes, lipid peroxidation, total cholesterol, triglycerides, creatinine, bilirubin and urea when compared to rats of Groups III - VI. Non-statistically significant lower activities (P0.05) of antioxidant enzymes and lipid profile status were observed in rats of Groups III and IV when compared with rats of Group VI. Evaluations of creatinine, urea and bilirubin levels in sera samples of rats of Groups III - V showed non-statistically significant lower levels (P≤0.05) of kidney functions tests when compared to rats of Group VI. This study concluded that Musa sapientum attenuated total antioxidant and lipid profile values; served reno-protective functions in rats with Indomethacin-induced gastric ulceration.
- Subjects
ANTIOXIDANTS &; health; BANANAS; LABORATORY rats; OMEPRAZOLE; GLUTATHIONE; SUPEROXIDE dismutase; CATALASE; THERAPEUTICS
- Publication
Cell Membranes & Free Radical Research, 2013, Vol 5, Issue 1, p236
- ISSN
1308-416X
- Publication type
Article