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- Title
Melanoma M (Zero): Diagnosis and Therapy.
- Authors
Rastrelli, Marco; Alaibac, Mauro; Stramare, Roberto; Sileni, Vanna Chiarion; Montesco, Maria Cristina; Vecchiato, Antonella; Campana, Luca Giovanni; Rossi, Carlo Riccardo
- Abstract
This paper reviews the epidemiology, diagnosis, and treatment of M zero cutaneous melanoma including the most recent developments. This review also examined the main risk factors for melanoma. Tumor thickness measured according to Breslow, mitotic rate, ulceration, and growth phase has the greatest predictive value for survival and metastasis. Wide excision of the primary tumor is the only potentially curative treatment for primary melanoma. The sentinel node biopsy must be performed on all patients who have a primary melanoma with a Breslow thickness > 1 mm, or if the melanoma is from0,75mmto 1mmthick but it is ulcerated and/or the mitotic index is ≥1. Total lymph node dissection consists in removing the residual lymph nodes in patients with positive sentinel node biopsy, or found positive on needle aspiration biopsy, without radiological evidence of spread. Isolated limb perfusion and isolated limb infusion are employed in patients within transit metastases with a rate of complete remission in around 50% and 38% of cases. Electrochemotherapy is mainly indicated for palliation in cases of metastatic disease, though it may sometimes be useful to complete isolated limb perfusion. The only agent found to affect survival as an adjuvant treatment is interferon alpha-2. Adjuvant radiotherapy improves local control of melanoma in patients at a high risk of recurrence after lymph node dissection.
- Subjects
MELANOMA diagnosis; MELANOMA treatment; AGE distribution; CANCER patients; DERMATOLOGY; SURGICAL excision; PATIENT aftercare; IMMUNOTHERAPY; LYMPH node surgery; MELANOMA; NEVUS; GENETIC mutation; RADIOTHERAPY; OPERATIVE surgery; SURVIVAL; TUMOR classification; WHITE people; DISEASE complications; CANCER risk factors
- Publication
ISRN Dermatology, 2013, p1
- ISSN
2090-4592
- Publication type
Article
- DOI
10.1155/2013/616170