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- Title
Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells.
- Authors
Mititelu, Magdalena; Moroșan, Elena; Nicoară, Anca Cecilia; Secăreanu, Ana Andreea; Musuc, Adina Magdalena; Atkinson, Irina; Pandele Cusu, Jeanina; Nițulescu, George Mihai; Ozon, Emma Adriana; Sarbu, Iulian; Balaci, Teodora Dalila
- Abstract
Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing calcium lactate obtained from Black Sea mussel shells. Compared with other calcium salts, calcium lactate has good solubility and bioavailability. In the pharmaceutical preparations, calcium lactate was extensively utilized as a calcium source for preventing and treating calcium deficiencies. The physical and chemical characteristics of synthesized calcium lactate were evaluated using Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis and thermal analysis. Further, the various pharmacotechnical properties of the calcium lactate obtained from mussel shells were determined in comparison with an industrial used direct compressible Calcium lactate DC (PURACAL®). The obtained results suggest that mussel shell by-products are suitable for the development of chemical compounds with potential applications in the pharmaceutical domain.
- Subjects
MYTILIDAE; SEASHELLS; FOURIER transform infrared spectroscopy; CALCIUM; LACTATES
- Publication
Marine Drugs, 2022, Vol 20, Issue 1, p45
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md20010045