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- Title
Prospective Study: Frequency of Ophthalmic Findings, Relationship with Inflammation Markers, and Effect on Prognosis in Patients Treated in the COVID-19 Intensive Care Unit.
- Authors
Ay, İbrahim Ethem; Alay, Demet
- Abstract
Objectives: To prospectively evaluate the frequency of ocular findings and inflammation markers levels in patients treated in the intensive care unit due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to determine the relationship between these parameters and mortality. Materials and Methods: We prospectively evaluated 53 patients who were treated in the intensive care unit of a pandemic hospital between January 1 and June 30, 2021 and whose SARS-CoV-2 diagnosis was confirmed by reverse transcriptase polymerase chain reaction test from nasopharyngeal swab samples. Ocular findings were evaluated together with white blood cell, neutrophil, lymphocyte count, C-reactive protein, lactate dehydrogenase and ferritin levels, and mortality rate. Results: There was no statistically significant correlation between lactate dehydrogenase, white blood cell, neutrophil, and lymphocyte count elevation and the frequency of inflammatory eye signs (p=0.308, p=0.694, p=0.535, p=0.374). In multivariate analyses, no statistically significant correlation was observed between ferritin level and the frequency of inflammatory eye findings (p=0.087). In addition, for each 1 mg/dL increase in C-reactive protein level, the detection of inflammatory eye findings decreased by 1.9% (95% confidence interval: 3.3%-0.4%; p=0.015). It was determined that 7 of 13 patients with inflammatory eye findings died and this was not statistically significant (p=0.810). Conclusion: Inflammatory examination findings of the ocular surface were detected in 13 (24.5%) of 53 patients treated in the intensive care unit for SARS-CoV-2 infection. Ocular surface examination of patients treated in the intensive care unit due to the SARSCoV- 2 epidemic is important.
- Subjects
TURKEY; BIOMARKERS; INTENSIVE care units; COVID-19; INFLAMMATION; HOSPITAL mortality; RISK assessment; CRITICAL care medicine; DESCRIPTIVE statistics; EYE diseases; LONGITUDINAL method
- Publication
Turkish Journal of Ophthalmology / Turk Oftalmoloji Dergisi, 2022, Vol 52, Issue 1, p6
- ISSN
1300-0659
- Publication type
Article
- DOI
10.4274/tjo.galenos.2021.05005